Who's driving the centromere?
نویسنده
چکیده
Centromere function is remarkably conserved between species, yet the satellite sequences that make up centromeric DNA are highly divergent. Proteins that bind these sequences appear to be evolving under positive selection, supporting a model wherein the interplay between centromeric repeats and the proteins that bind them creates an opportunity for an intriguing phenomenon known as centromere-based meiotic drive.
منابع مشابه
Genetic Conflicts: Stronger Centromeres Win Tug-of-War in Female Meiosis
Female meiosis presents unique opportunities for competition between chromosomes for evolutionary dominance. A new study reveals that centromere strength dictates meiotic success, driving karyotype evolution and reproductive isolation in mice.
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Centromeres are crucial regions on each chromosome that direct several functions that are essential for life. They aggregate the proteins that make up the kinetochore, the chromosomal attachment point for the microtubules that form the meiotic or mitotic spindle, and they are responsible for the proper segregation of chromosomes into daughter cells at each division, as well as ensuring proper p...
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عنوان ژورنال:
- Journal of Biology
دوره 3 شماره
صفحات -
تاریخ انتشار 2004